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Questions And Answer

• Reaction

  1. Biaryl bisphosphine ligand with narrow dihedral angle. The DTBM SEGPHOS® ligand, as the ruthenium complex, gives superior enantioselectivity and diastereoselectivity through dynamic kinetic resolution in the asymmetric hydrogenation of a-substituted-β-ketoesters useful in the synthesis of carbapenum antibiotics.
  2. With rhodium, preferential enantioselective hydrogenation of more reactive olefin of extended enone structure.
  3. Rhodium catalyzed chemo-, regio, and entantioselective [2 + 2 + 2] cycloaddition of alkynes with isocyanates.
  4. With copper, enantioselective cross Aldol-type reaction of acetonitrile.
  5. With copper, enantioselective vinylsilane alkenylation of aldehydes.
  6. Gold carbene mediated stereoselective cyclopropanation of propargyl esters.
  7. With copper, enantioselective 1,2-reduction of ketones, and 1,4-reduction of a α,β-usaturated esters.
  8. With copper, catalytic enantioselective Mannich-type reaction.
  9. Enantioselective fluorination of b β-keto esters, tert-butoxycarbonyl lactones and lactmes with Sodeoka's Pd-aqua complex and a fluorinating reagent.
  10. Rh-catalyzed intramolecular olefin or carbonyl hydroacylation.
  
  
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