ChemicalBook CAS DataBase List 201341-05-1

201341-05-1

Name	Tenofovir disoproxil
CAS	201341-05-1
EINECS(EC#)	111-111-1
Molecular Formula	C19H30N5O10P
MDL Number	MFCD00952920
Molecular Weight	519.44
MOL File	201341-05-1.mol

Synonyms

Tdf SRY Aids080741 Aids-080741 Bis(poc)pmpa Pmpa prodrug Tenofov ir Disoprox Tenofovir disoproxil Testis-determining factor Tenofovir disoproxil, >=98% TenofivirDisoproxilFumarate Tenofovir disoproxil aspartate 202138-50-9 (1:1 Fumarate salt) Gs 4331-05 (*1:1 fumarate salt*) Tenofovirdisoproxil(Fumaratesalt) Bis(isopropyloxymethylcarbonyl)pmpa 9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine (R)-(((((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)-bis(oxy))bis(methylene) d (R)-(((((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)-bis(oxy))bis(methylene) diis (R)-(((((1-(6-AMino-9H-purin-9-yl)propan-2-yl)oxy)Methyl)phosphoryl)bis(oxy))bis(Methylene) diisopropyl dicarbonate 5-[[(1r)-2-(6-Amino-9h-Purin-9-Yl)-1-Methylethoxy]Methyl]-2,4,6,8-Tetraoxa-5-Phosphanononanedioic Acid Bis(1-Methylethyl) Ester 5-Oxide 2,4,6,8-Tetraoxa-5-phosphanonanedioicacid, 5-[[(1R)-2-(6-aMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-,1,9-bis(1-Methylethyl) ester, 5-oxide

Chemical Properties

Boiling point	642.7±65.0 °C(Predicted)
density	1.45±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO: ≥ 38 mg/mL (73.16 mM)
pka	4.20±0.10(Predicted)
CAS DataBase Reference	201341-05-1

Hazard Information

Definition

ChEBI: An organic phosphonate that is the disoproxil ester of tenofovir. A prodrug for tenofovir, an HIV-1 reverse transcriptase inhibitor, tenofovir disoproxil is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.

Uses

Tenofovir Disoproxil is a therapeutic option for nucleos(t)ide analog (NA)-experienced chronic hepatitis B (CHB) patients infected with hepatitis B virus (HBV). Also, it is an intermediate used in the synthesis of Tenofovir Disoproxil Dimer (T018515), which is a Tenofovir Disoproxil impurity.

General Description

Tenofovir disoproxil is a prodrug analogously with abacavir.Plasma and tissue esterases cleave the phosphateprotecting groups, releasing the active drug. The bioavailabilityof tenofovir is about 35% when administered withfood. The drug is approved by the Food and DrugAdministration (FDA) for the treatment of HIV infectionsin adult patients. Recommendations are for the drug to beadministered with other RT inhibitors or PIs to achievesynergism.

Clinical Use

Nucleoside reverse transcriptase inhibitor:
Treatment of HIV in combination with other antiretroviral drugs
Treatment of hepatitis B in compensated liver disease

Drug interactions

Potentially hazardous interactions with other drugs
Antivirals: avoid with adefovir and cidofovir; reduces concentration of atazanavir, also concentration of tenofovir possibly increased; increased didanosine concentration resulting in increased toxicity (e.g. pancreatitis and lactic acidosis) - avoid; concentration increased by lopinavir and telaprevir.
Co-administration with other drugs that are actively secreted via the tubular anionic transporter.
Orlistat: absorption possibly reduced by orlistat.

Metabolism

Tenofovir is excreted mainly in the urine by both active tubular secretion and glomerular filtration.

storage

Store at -20°C

Questions And Answer

Supplier

Huangshi Fuertai Pharmaceutical Tech Co., Ltd.

Telephone0714-3293168-6021 13995956430

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList31159/0.htm

Wuhan Runzeweiye Technology Co., Ltd.

Telephone027-50779735 15172337137

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList20046/0.htm

Adamas Reagent, Ltd.

Telephone400-6009262 16621234537

Websitehttp://www.tansoole.com

NOTA Chemical (Shanghai) Co.,Ltd

Telephone021-50189163

Websitehttp://www.notachem.com/

Shanghai Hanhong Scientific Co.,Ltd.

Telephone021-54306202 13764082696;

Websitehttps://www.hanhongsci.com

XiaoGan ShenYuan ChemPharm co,ltd

Telephone0712-0712-2580635 15527768850

Websitehttp://www.farchem.com/

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Telephone+8618575662672 18575662672

Websitehttp://www.sunwaypharm.com

Wuhan Fortuna Chemical Co., Ltd

Telephone027-027-59207852 13308628970

Websitehttp://www.fortunachem.cn

ShangHai YuanYe Biotechnology Co., Ltd.

Telephone021-61312847 13636370518

Websitehttp://www.shyuanye.com

Beijing HuaMeiHuLiBiological Chemical

Telephone010-56205725

Websitehttp://www.huabeibiochem.com/

China Nobel Chem Co., Limited

Telephone+86(0)21 60484900

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList15874/0.htm

Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.

Telephone+86-28-85122536 85324413

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList12313/0_EN.htm

Nanjing Sunlida Biological Technology Co., Ltd.

Telephone025-57798810

Websitehttp://www.sunlidabio.com

Zouping Mingxing Chemical Co.,Ltd.

Telephone86-13605431940 13605431940

Websitehttp://www.zoutong.com.cn

TargetMol Chemicals Inc.

Telephone021-33632979 15002134094

Websitehttps://www.targetmol.cn/

ShangHai Caerulum Pharma Discovery Co., Ltd.

Telephone 18149758185

Websitehttp://www.caerulumpharma.com

Hubei XinyuanShun Chemical Co., Ltd.

Telephone13971561712, 13995564702, 027-50664929

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16209/0.htm

Eastbang Pharmaceuticals Technology Co., Ltd.

Telephone+86 (20) 28996708,29078958,28139708,29076128,28133708,28139728,28139738,28133718,021-31663278,021-31663578,021-60538387

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList13633/0.htm

1of4

Related Products

Send Inquriy