147245-92-9

Glatiramer acetate is a random basic synthetic copolymer of L-alanine, L-lysine, l-glutamic acid and L-tyrosine in a molar ratio of 6:1.9:4.7:1. Glatiramer acetate is an immunomodulator used in treatment of multiple sclerosis.

Copaxone,Teva Pharmaceuticals,Israel

Glatiramer Acetate is water soluble copolypeptide with molecular weight 15,000-25,000.
Copolymer is prepared by copolymerization of the N-carboxyanhydrides of tyrosine, alanine, lysine, and glutamic acid. The polymerisation was carried out at ambient temperature in anhydrous dioxane with diethylamine as initiator. Glatiramer Acetate have the ratio alanin:glutamic acid:lysine:tyrosine = 1:6:4.54:2.

Copaxone (Teva).

Immunomodulator

Immunomodulating drug:

Treatment for patients at a high risk of developing multiple sclerosis and for reduction in relapses in ambulatory patients

Potentially hazardous interactions with other drugs
None known

A substantial fraction of a subcutaneous dose of glatiramer is believed to be hydrolysed locally. Some of the injected dose is also presumed to enter the lymphatic system, either intact or partially hydrolysed.