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10238-21-8

Name 5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]-amino]sulfonyl]phenyl]-ethyl]-2-methoxybenzamide
CAS 10238-21-8
EINECS(EC#) 233-570-6
Molecular Formula C23H28ClN3O5S
MDL Number MFCD00056625
Molecular Weight 494
MOL File 10238-21-8.mol

Chemical Properties

Appearance White Crystalline Powder
Melting point  173-175°C
density  1.1805 (rough estimate)
refractive index  1.6100 (estimate)
storage temp.  2-8°C
solubility  ethanol: soluble2mg/mL
form  White solid
pka 5.3(at 25℃)
color  White
Water Solubility  Soluble in ethanol (5 mg/mL), DMSO (25 mg/mL), chloroform (1:36), methanol (1:250), and DMF. Insoluble in water.
Usage A second generation sulfonylurea with hypoglycemic activity
Merck  13,4491
BCS Class 2
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey ZNNLBTZKUZBEKO-UHFFFAOYSA-N
CAS DataBase Reference 10238-21-8(CAS DataBase Reference)
NIST Chemistry Reference Glyburide(10238-21-8)
EPA Substance Registry System Benzamide, 5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy- (10238-21-8)

Safety Data

Hazard Codes  Xn
Risk Statements 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
Safety Statements 
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S36:Wear suitable protective clothing .
WGK Germany  2
RTECS  YS4725200
HS Code  29350090
Toxicity
LD50 in rats and mice (g/kg): >20 orally; >12.5 i.p.; >20 s.c. (Mizukami)

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